SpotRM supports your decisions on important safety aspects of new drug structures by pointing out potentially bad motifs/structural features that can cause reactive metabolites. This web-based tool collects extensive knowledge in a format that allows quick access to the original literature. By regularly using it, you will quickly gain an understanding of why and how misdirected metabolism can be a grave problem. Whenever possible, guidance to avoid or replace the particular structural alert is given.
The basic principles and the design and selection of the structural alerts have been reviewed in a perspective paper: A. Claesson & A. Minidis, Chem. Res. Toxicol. 2018