Abbreviations used within SpotRM

ADR
adverse drug reaction
AE
adverse event
COX
cyclooxygenase
CYP
cytochrome P450
DILI
drug induced liver injury
DRESS
drug reaction with eosinophilia and systemic symptoms
EMA
European Medicines Agency
FDA
Food and Drug Administration (USA)
GSH
glutathione
GST
glutathione transferase
HLM
human liver microsomes
HRP
horseradish peroxidase
HSA
human serum albumin
IADR
idiosyncratic adverse drug reaction
MAO
monoamine oxidase
MBI
mechanism-based inhibition
MIST
metabolites in safety testing inhibition
MPO
myeloperoxidase
NSAID
nonsteroidal anti-inflammatory drug
RM
reactive metabolite
SULT
sulfotransferase
TDI
time-dependent inhibition
UGT
UDP-glucuronosyltransferase
ULN
upper level of normal